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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11918650 B1

PDFFull Text
Date of Patent:
Mar. 05, 2024

Filed:

May. 07, 2018

Pharmaceutical composition comprising bispecific antibody constructs for improved storage and administration

Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

Jeff Abel, Simi Valley, CA (US);

Lingwen Cui, Thousand Oaks, CA (US);

Devrishi Goswami, Thousand Oaks, CA (US);

Joon Huh, Culver City, CA (US);

Bharadwaj Jagannathan, Thousand Oaks, CA (US);

Sekhar Kanapuram, Thousand Oaks, CA (US);

Arnold McAuley, Moorpark, CA (US);

Michael Schneider, Thousand Oaks, CA (US);

Ananthakrishnan G. Sethuraman, Newbury Park, CA (US);

Michael Treuheit, Newbury Park, CA (US);

Jun Zhang, Newbury Park, CA (US);

Assignee:

AMGEN INC., Thousand Oaks, CA (US);

Attorney:

MARSHALL, GERSTEIN & BORUN LLP

Primary Examiner:

Meera Natarajan

Int. Cl.
CPC ...
A61K 39/395 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 9/19 (2006.01); A61K 47/10 (2017.01); A61K 47/12 (2006.01); A61K 47/14 (2017.01); A61K 47/18 (2017.01); A61K 47/24 (2006.01); A61K 47/26 (2006.01); C07K 16/28 (2006.01); C07K 16/46 (2006.01); A61J 1/05 (2006.01); A61J 1/10 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39591 (2013.01); A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 9/19 (2013.01); A61K 39/3955 (2013.01); A61K 47/10 (2013.01); A61K 47/12 (2013.01); A61K 47/14 (2013.01); A61K 47/183 (2013.01); A61K 47/24 (2013.01); A61K 47/26 (2013.01); C07K 16/2803 (2013.01); C07K 16/2809 (2013.01); C07K 16/2863 (2013.01); C07K 16/468 (2013.01); A61J 1/05 (2013.01); A61J 1/10 (2013.01); A61K 2039/54 (2013.01); A61K 2039/545 (2013.01); A61K 2039/627 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01); C07K 2317/41 (2013.01); C07K 2317/569 (2013.01);
Abstract

The present invention provides an improved pharmaceutical composition for storage and administration comprising (a) a bispecific antibody construct comprising a first domain binding to a target cell surface antigen and a second domain binding to a second antigen, wherein the bispecific antibody construct is present at a concentration in the range from about 0.5 μg/ml to 20 mg/ml, (b) a preservative at a concentration effective to inhibit the growth of microbes, and (c) a diluent wherein bispecific antibody construct is stable and recoverable.

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