The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 27, 2024

Filed:

Oct. 27, 2021
Applicant:

Glaxosmithkline Biologicals SA, Rixensart, BE;

Inventor:

Andrew Geall, Littleton, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/117 (2010.01); C12N 15/86 (2006.01); A61K 39/155 (2006.01); A61K 39/39 (2006.01); A61K 39/12 (2006.01); A61P 31/12 (2006.01); A61P 37/04 (2006.01); A61K 39/00 (2006.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/117 (2013.01); A61K 39/12 (2013.01); A61K 39/155 (2013.01); A61K 39/39 (2013.01); A61K 48/0041 (2013.01); A61K 48/0083 (2013.01); A61P 31/12 (2018.01); A61P 37/04 (2018.01); C12N 15/86 (2013.01); A61K 2039/53 (2013.01); A61K 2039/552 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/55566 (2013.01); C12N 2760/18534 (2013.01); C12N 2770/36143 (2013.01); C12N 2820/60 (2013.01);
Abstract

Provided is RNA encoding an immunogen is delivered to a large mammal at a dose of from 5 μg to 100 μg or at a dose between 0.1 μg per kilogram body mass of the large mammal and 1.5 μg per kilogram body mass of the large mammal. Provided is a method of raising an immune response in a large mammal, comprising administering to the large mammal a dose of from 5 μg to 100 μg or a dose of between 0.1 μg of RNA encoding the immunogen per kilogram body mass of the large mammal and 1.5 μg of RNA encoding the immunogen per kilogram body mass of the large mammal. The delivered RNA can elicit an immune response in the large mammal.


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