logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11912719 B1

PDFFull Text
Date of Patent:
Feb. 27, 2024

Filed:

Dec. 29, 2021

Substituted isoquinolines as rock kinase inhibitors

Applicant:

Cervello Therapeutics Llc, Malvern, PA (US);

Inventors:

Matthew Randolph Lee, Del Mar, CA (US);

Anthony Joseph Varano, Jr., Berwyn, PA (US);

Thomas P. Bobinski, San Diego, CA (US);

Assignee:

Cervello Therapeutics, LLC., Malvern, PA (US);

Attorney:

Wood, Phillips, Katz, Clark & Mortimer

Primary Examiner:

Douglas M Willis

Int. Cl.
CPC ...
A61K 31/4725 (2006.01); C07D 217/22 (2006.01); C07D 498/08 (2006.01); C07D 401/12 (2006.01); C07D 405/14 (2006.01); C07D 471/04 (2006.01); C07D 403/12 (2006.01);
U.S. Cl.
CPC ...
C07D 498/08 (2013.01); C07D 401/12 (2013.01); C07D 403/12 (2013.01); C07D 405/14 (2013.01); C07D 471/04 (2013.01);
Abstract

The present invention relates to indoline-based compounds that inhibit Rho-associated protein kinase (ROCK) activity. In particular, the present invention relates to compounds, pharmaceutical compositions and methods of use, such as methods of inhibiting ROCK activity and methods for treating, for example cerebral cavernous malformation syndrome (CCM) and cardiovascular diseases using the compounds and pharmaceutical compositions of the present invention.

Find Patent Forward Citations

Lee, Matthew. (2024). Substituted isoquinolines as rock kinase inhibitors (U.S. Patent No. 11912719). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11912719

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

Loading…