The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2024
Filed:
Jul. 16, 2019
Applicant:
Heparegenix Gmbh, Tübingen, DE;
Inventors:
Wolfgang Albrecht, Ulm, DE;
Stefan Laufer, Tübingen, DE;
Roland Selig, Ulm, DE;
Phillip Klövekorn, Pliezhausen, DE;
Bent Präfke, Tübingen, DE;
Assignee:
HepaRegeniX GmbH, Tübingen, DE;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C07D 471/04 (2006.01);
U.S. Cl.
CPC ...
C07D 471/04 (2013.01);
Abstract
The invention relates to compounds of formula (I) which are inhibitors of MKK4 (mitogen-activated protein kinase kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The compounds selectively inhibit protein kinase MKK4 over protein kinases JNK and MKK7. (I), wherein R, R, Rand Rare selected from: a) Rand Rare F and Rand Rare H; b) R, Rand Rare independently halogen and Ris H; c) RRand Rare independently halogen and Ris H; and d) RRand Rare independently halogen and Ris H.