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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11912679 B1

PDFFull Text
Date of Patent:
Feb. 27, 2024

Filed:

Sep. 26, 2023

Aryl alkynamide derivatives

Applicants:

Astellas Pharma, Inc., Tokyo, JP;

Mitobridge, Inc., Cambridge, MA (US);

Inventors:

Junko Maeda, Tokyo, JP;

Ikumi Kuriwaki, Tokyo, JP;

Kai Kitamura, Tokyo, JP;

Yumi Yamashita, Tokyo, JP;

Kenichi Kakefuda, Tokyo, JP;

Akio Kamikawa, Tokyo, JP;

Kenji Negoro, Tokyo, JP;

Wataru Hamaguchi, Tokyo, JP;

Ryushi Seo, Tokyo, JP;

Jeffrey Ciavarri, Cambridge, MA (US);

Assignees:

Astellas Pharma, Inc., Tokyo, JP;

Mitobridge, Inc., Cambridge, MA (US);

Attorneys:

McCarter & English, LLP

Wei Song

James M. Alburger

Primary Examiner:

Samantha L Shterengarts

Assistant Examiner:

Karen Cheng

Int. Cl.
CPC ...
C07C 233/69 (2006.01); C07C 233/22 (2006.01); C07C 233/81 (2006.01); C07C 235/42 (2006.01); C07C 237/42 (2006.01); C07C 311/13 (2006.01); C07C 311/46 (2006.01); C07D 205/04 (2006.01); C07D 207/12 (2006.01); C07D 207/16 (2006.01); C07D 207/273 (2006.01); C07D 209/08 (2006.01); C07D 211/48 (2006.01); C07D 211/62 (2006.01); C07D 213/56 (2006.01); C07D 213/75 (2006.01); C07D 231/12 (2006.01); C07D 231/40 (2006.01); C07D 239/26 (2006.01); C07D 279/12 (2006.01); C07D 295/155 (2006.01); C07D 295/16 (2006.01); C07D 295/195 (2006.01); C07D 305/08 (2006.01); C07D 307/22 (2006.01); C07D 309/14 (2006.01); C07D 333/48 (2006.01); C07D 401/06 (2006.01); C07D 403/06 (2006.01); C07D 403/10 (2006.01); C07D 405/10 (2006.01); C07D 487/10 (2006.01);
U.S. Cl.
CPC ...
C07D 295/16 (2013.01); C07C 233/22 (2013.01); C07C 233/69 (2013.01); C07C 233/81 (2013.01); C07C 235/42 (2013.01); C07C 237/42 (2013.01); C07C 311/13 (2013.01); C07C 311/46 (2013.01); C07D 205/04 (2013.01); C07D 207/12 (2013.01); C07D 207/16 (2013.01); C07D 207/273 (2013.01); C07D 209/08 (2013.01); C07D 211/48 (2013.01); C07D 211/62 (2013.01); C07D 213/56 (2013.01); C07D 213/75 (2013.01); C07D 231/12 (2013.01); C07D 231/40 (2013.01); C07D 239/26 (2013.01); C07D 279/12 (2013.01); C07D 295/155 (2013.01); C07D 295/195 (2013.01); C07D 305/08 (2013.01); C07D 307/22 (2013.01); C07D 309/14 (2013.01); C07D 333/48 (2013.01); C07D 401/06 (2013.01); C07D 403/06 (2013.01); C07D 403/10 (2013.01); C07D 405/10 (2013.01); C07D 487/10 (2013.01);
Abstract

[Problem] A compound which is useful as a STING inhibitor is provided. [Means for Solution] The present inventors have found aryl alkynamide derivatives having an inhibitory action on STING. The aryl alkynamide derivatives of the present invention have an inhibitory action on STING and can be used as an agent for treating an autoimmune disease, a neurodegenerative disease, a type I interferonopathy and/or other STING-mediated disease.

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