The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2024
Filed:
Aug. 04, 2020
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Martin G. Pomper, Baltimore, MD (US);
Ronnie C. Mease, Fairfax, VA (US);
Sangeeta Ray, Ellicott City, MD (US);
Ying Chen, Lutherville-Timonium, MD (US);
Xing Yang, Balitmore, MD (US);
Assignee:
THE JOHNS HOPKINS UNIVERSTY, Baltimore, MD (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 51/04 (2006.01); A61K 41/00 (2020.01); A61K 49/00 (2006.01); C07D 213/82 (2006.01); C07D 209/12 (2006.01); C07C 271/22 (2006.01); C07C 275/16 (2006.01); C07C 323/62 (2006.01);
U.S. Cl.
CPC ...
A61K 51/0402 (2013.01); A61K 41/0057 (2013.01); A61K 49/0002 (2013.01); A61K 49/0021 (2013.01); A61K 49/0032 (2013.01); A61K 49/0041 (2013.01); A61K 49/0052 (2013.01); A61K 51/0455 (2013.01); C07C 271/22 (2013.01); C07C 275/16 (2013.01); C07C 323/62 (2013.01); C07D 209/12 (2013.01); C07D 213/82 (2013.01); A61K 49/0017 (2013.01); A61K 49/0019 (2013.01);
Abstract
Carbamate and beta-amino acid urea-based scaffolds that have high binding affinity to PSMA are disclosed. These scaffolds can be radiolabeled and used for imaging cells and tumors that express PSMA or for cancer radiotherapy. These compounds also can comprise a fluorescent dye and be used for imaging cells and tumors that express PSMA or for photodynamic therapy.