The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2024
Filed:
Dec. 18, 2020
Modified self-immolating moieties for use in prodrugs and conjugates and methods of using and making
Applicant:
Bristol-myers Squibb Company, Princeton, NJ (US);
Inventors:
Yam B. Poudel, Fremont, CA (US);
Sanjeev Gangwar, Foster City, CA (US);
Assignee:
Bristol-Myers Squibb Company, Princeton, NJ (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 47/65 (2017.01); A61K 47/64 (2017.01); A61K 47/68 (2017.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
A61K 47/65 (2017.08); A61K 45/06 (2013.01); A61K 47/6425 (2017.08); A61K 47/6865 (2017.08); A61P 35/00 (2018.01);
Abstract
Compounds represented by formula (I) can be used to make antibody-drug conjugates. The conjugates so made are stable in both human and mouse serum, enabling the performance of pre-clinical studies using a mouse model.