The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 27, 2024
Filed:
Jun. 09, 2016
Applicant:
Editas Medicine, Inc., Cambridge, MA (US);
Inventors:
Jennifer Leah Gori, Jamaica Plain, MA (US);
Tongyao Wang, Malden, MA (US);
Hariharan Jayaram, Cambridge, MA (US);
Penrose ODonnell, Yarmouth, ME (US);
Assignee:
Editas Medicine, Inc., Cambridge, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/078 (2010.01); A61K 35/14 (2015.01); C12N 15/113 (2010.01); C12N 15/31 (2006.01); G16B 50/00 (2019.01); A61K 35/28 (2015.01); G16B 40/00 (2019.01); C12N 15/11 (2006.01); C07K 14/74 (2006.01); C12N 5/0789 (2010.01); C12N 9/22 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
A61K 35/28 (2013.01); C07K 14/70539 (2013.01); C12N 5/0647 (2013.01); C12N 9/22 (2013.01); C12N 15/11 (2013.01); C12N 15/111 (2013.01); C12N 15/86 (2013.01); G16B 40/00 (2019.02); G16B 50/00 (2019.02); C12N 2310/20 (2017.05);
Abstract
Disclosed herein are compositions and methods for increasing the immunocompatibility of donor cells (e.g., HSCs or T-cells) for transplantation to a recipient subject, as well as database schemes for use in the methods. The methods and compositions described herein result in the allele-specific modification of one or more immunogenicity genes (e.g., an HLA gene) of a cell, resulting in cells that are suitable for transplantation into a recipient subject.