The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2024
Filed:
Apr. 05, 2018
Applicant:
Modernatx, Inc., Cambridge, MA (US);
Inventors:
Luis Brito, Concord, MA (US);
Gilles Besin, Brookline, MA (US);
Assignee:
ModernaTX, Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/88 (2006.01); A61K 9/00 (2006.01); A61K 9/127 (2006.01); A61K 31/7105 (2006.01); A61K 47/12 (2006.01); A61K 47/28 (2006.01);
U.S. Cl.
CPC ...
C12N 15/88 (2013.01); A61K 9/0019 (2013.01); A61K 9/1271 (2013.01); A61K 31/7105 (2013.01); A61K 47/12 (2013.01); A61K 47/28 (2013.01); C12N 2310/141 (2013.01);
Abstract
This disclosure provides improved lipid-based compositions, including lipid nanoparticle compositions, and methods of use thereof for delivering nucleic acids in vivo. These compositions have reduced immune activation resulting in accelerated blood clearance and/or anti-drug antibodies and they have an improved toxicity profile and therapeutic index in vivo.