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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11905522 B1

PDFFull Text
Date of Patent:
Feb. 20, 2024

Filed:

Jan. 15, 2019

Treatment of diseases by liver expression of an enzyme which has a deoxyribonuclease (dnase) activity

Applicant:

Cls Therapeutics Limited, Saint Peter Port, GG;

Inventors:

Dmitry Dmitrievich Genkin, Saint Petersburg, RU;

Georgy Viktorovich Tets, Saint Petersburg, RU;

Viktor Veniaminovich Tets, Saint Petersburg, RU;

Assignee:

CLS THERAPEUTICS LIMITED, Saint Peter Port, GG;

Attorneys:

ENTRALTA PLLC

Peter D. Weinstein

James F. Fleming

Primary Examiner:

Quang Nguyen

Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/04 (2006.01); C12N 15/63 (2006.01); C12N 15/00 (2006.01); C12N 15/86 (2006.01); C12N 9/22 (2006.01); A61K 38/46 (2006.01); A61P 35/04 (2006.01); A61P 25/28 (2006.01); A61P 1/16 (2006.01); C07K 14/005 (2006.01); G01N 33/53 (2006.01); C12Q 1/68 (2018.01); A01K 67/00 (2006.01); A61B 5/00 (2006.01); A61B 17/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/86 (2013.01); A61K 38/465 (2013.01); A61K 48/005 (2013.01); A61K 48/0058 (2013.01); A61P 1/16 (2018.01); A61P 25/28 (2018.01); A61P 35/04 (2018.01); C07K 14/005 (2013.01); C12N 9/22 (2013.01); C12Q 1/68 (2013.01); G01N 33/5308 (2013.01); A01K 2207/12 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0331 (2013.01); A61B 5/4848 (2013.01); A61B 2017/00893 (2013.01); C12N 2750/14122 (2013.01); C12N 2750/14143 (2013.01); C12N 2750/14145 (2013.01); C12N 2830/008 (2013.01); G01N 2333/435 (2013.01); G01N 2800/7028 (2013.01);
Abstract

The invention relates to the liver-specific delivery and/or expression of an enzyme which has a deoxyribonuclease (DNase) activity for enhanced clearance of cell free DNA (cfDNA) accumulated in hepatic porto-sinusoidal circulation and the use of such liver-specific delivery and/or expression for treatment of various diseases and conditions, including cancer and neurodegeneration.

Find Patent Forward Citations

Genkin, Dmitry. (2024). Treatment of diseases by liver expression of an enzyme which has a deoxyribonuclease (dnase) activity (U.S. Patent No. 11905522). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11905522

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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