The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2024
Filed:
Dec. 19, 2018
Verovaccines Gmbh, Halle/Saale, DE;
Hans Caspar Hührlimann, Leipzig, DE;
Martina Behrens, Halle, DE;
Mandy Gebauer, Schwerin, DE;
Karin Breunig, Berlin, DE;
Sven-Erik Behrens, Halle, DE;
VEROVACCINES GMBH, Halle/Saale, DE;
Abstract
The invention relates to recombinant() yeasts which are capable of the highly efficient expression of one or more foreign proteins and are suitable for use as a vaccine for generating a protective immune response against pathogens. The invention provides in particularstrains for the targeted cloning of foreign antigen-coding nucleic acids into the yeast genome of thestrain, which is characterized in that thestrain has integrated expression cassettes for foreign antigens as an alternative or in addition to the KILAC4 locus on the KIURA3-20 locus (KLLA0E22771g) and/or on the KIMET5-1 locus (KLLA0B03938g). The invention further relates to integrative expression vectors and to methods for producing thestrains of the invention as well as to the use thereof as vaccines.