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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11905249 B1

PDFFull Text
Date of Patent:
Feb. 20, 2024

Filed:

Jan. 25, 2021

Covalent inhibitors of equine encephalitis virus

Applicant:

Jackson State University, Jackson, MS (US);

Inventors:

Ifedayo Victor Ogungbe, Clinton, MS (US);

Huaisheng Zhang, Shanghai, CN;

Assignee:

Jackson State University, Jackson, MS (US);

Attorney:

Butler Snow LLP

Primary Examiner:

D Margaret M Seaman

Int. Cl.
CPC ...
C07D 215/06 (2006.01); C07D 215/18 (2006.01); C07C 317/28 (2006.01); C07D 209/42 (2006.01); C07D 241/42 (2006.01); C07C 237/36 (2006.01);
U.S. Cl.
CPC ...
C07D 215/06 (2013.01); C07C 237/36 (2013.01); C07C 317/28 (2013.01); C07D 209/42 (2013.01); C07D 215/18 (2013.01); C07D 241/42 (2013.01);
Abstract

Embodiments and methods for a new class of potent non-peptidic covalent inhibitors of nsP2 cysteine protease that inhibit Venezuelan equine encephalitis virus's (VEEV) replication in neuroblasts are disclosed. More particularly, an acrylate and vinyl sulfone-based chemical series were investigated as promising starting scaffolds against VEEV and as inhibitors of the cysteine protease domain of VEEV's non-structural protein 2 (nsP2). The invention discloses compounds of Formula I and analogues for treatment of VEEV.

Find Patent Forward Citations

Ogungbe, Ifedayo. (2024). Covalent inhibitors of equine encephalitis virus (U.S. Patent No. 11905249). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11905249

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