The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 20, 2024

Filed:

Sep. 15, 2021
Applicant:

Xwpharma Ltd., Grand Cayman, KY;

Inventors:

Jia-Ning Xiang, Fremont, CA (US);

Xuesong Xu, Wuhan, CN;

Yi Feng, Wuhan, CN;

Xianbo Liu, Wuhan, CN;

Wai-Si Eng, Maple Glen, PA (US);

Assignee:

XWPHARMA LTD., Grand Cayman, KY;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 211/56 (2006.01); A61P 1/08 (2006.01); A61K 9/00 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07D 211/56 (2013.01); A61P 1/08 (2018.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 45/06 (2013.01);
Abstract

The present invention relates compounds of Formula (A) as NK-1 receptor antagonists, as well as their preparation and uses, and further relates pharmaceutical compositions comprising these compounds and their uses as modulators of dysfunctional glutamate transmission. The present invention also relates to the uses of the compounds or pharmaceutical compositions in treating or preventing certain disorders and diseases which relate to NK-1 receptor in humans. More specifically, the compounds and/or pharmaceutical compositions of the present invention are believed to potentially offer therapeutic benefits to patients who suffer, among others, chemotherapy-induced nausea and vomit (CINV) and/or post-operative nausea and vomit (PONV).


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