The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2024
Filed:
Mar. 18, 2022
Bicycle TX Limited, Cambridge, GB;
Paul Brennan, Cambridge, GB;
Amy Brown, Cambridge, GB;
Liuhong Chen, Cambridge, GB;
John Davis, Cambridge, GB;
Yuliya Demydchuk, Cambridge, GB;
Donatella Di Rienzo, Cambridge, GB;
Ellen Gowans, Cambridge, GB;
Rama McCrory, Cambridge, GB;
Emma Mead, Cambridge, GB;
Emma Murphy, Cambridge, GB;
Mike Rigby, Cambridge, GB;
Michael Skynner, Cambridge, GB;
Tom Smith, Cambridge, GB;
Steven Stanway, Cambridge, GB;
BicycleTx Limited, Cambridge, GB;
Abstract
The present invention relates to polypeptides which are covalently bound to molecular scaffolds such that two or more peptide loops are subtended between attachment points to the scaffold. In particular, the invention describes peptides which bind to TREM2. The invention also relates to multimeric binding complexes which comprise at least two of said bicyclic peptide ligands. The invention also includes pharmaceutical compositions comprising said peptide ligands and multimeric binding complexes and the use of said peptide ligands, multimeric binding complexes and pharmaceutical compositions in preventing, suppressing or treating a disease or disorder mediated by TREM2.