The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2024
Filed:
May. 03, 2019
Applicant:
Viacyte, Inc., San Diego, CA (US);
Inventors:
Anindita Bhoumik, San Diego, CA (US);
Alan D. Agulnick, San Diego, CA (US);
Kevin Allen D'Amour, San Diego, CA (US);
Assignee:
ViaCyte, Inc., San Diego, CA (US);
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 39/00 (2006.01); C12N 5/0735 (2010.01); C12N 5/074 (2010.01); A61K 48/00 (2006.01); A61K 35/39 (2015.01); C12N 5/071 (2010.01);
U.S. Cl.
CPC ...
A61K 39/001 (2013.01); A61K 35/39 (2013.01); A61K 48/00 (2013.01); C12N 5/0606 (2013.01); C12N 5/0676 (2013.01); C12N 5/0696 (2013.01); C12N 2501/24 (2013.01); C12N 2501/50 (2013.01); C12N 2501/599 (2013.01); C12N 2501/998 (2013.01); C12N 2506/02 (2013.01); C12N 2510/00 (2013.01);
Abstract
Disclosed herein are universal donor stem cells and cells derived therefrom and related methods of their use and production. The universal donor stem cells disclosed herein are useful for overcoming allogeneic immune rejection in cell-based transplantation therapies. In certain embodiments, the universal donor cells disclosed herein are pancreatic endoderm cells that do not express one or more MHC-Class I cell-surface proteins and whose expression of at least one NK activating ligand is disrupted or inhibited.