The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2024
Filed:
Oct. 15, 2018
Applicant:
University of Cincinnati, Cincinnati, OH (US);
Inventors:
Xiaoyang Qi, Cincinnati, OH (US);
Nikhil Shukla, Carmel, IN (US);
Assignee:
University of Cincinnati, Cincinnati, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/18 (2006.01); A61P 35/00 (2006.01); A61K 9/51 (2006.01); A61K 31/685 (2006.01); C12N 15/115 (2010.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/18 (2013.01); A61K 9/51 (2013.01); A61K 31/685 (2013.01); A61P 35/00 (2018.01); C12N 15/115 (2013.01); A61K 9/0019 (2013.01);
Abstract
A method of inducing cell death in a glioblastoma multiforme cancer cell is provided, the method comprising administering to the cell a combination of therapeutic agents comprising: saposin C and dioleoylphosphatidylserine (SapC-DOPS), and nucleolin aptamer AS1411, wherein cell death of the cancer cell is induced. Also provided are methods of treating glioblastoma multiforme, methods of inhibiting growth of a glioblastoma multiforme tumor, kits, and pharmaceutical compositions comprising SapC-DOPS and AS1411.