The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 20, 2024
Filed:
Jul. 20, 2018
Applicant:
Cellectis, Paris, FR;
Inventors:
Philippe Duchateau, Draveil, FR;
Anne-Sophie Gautron, Etrechy, FR;
Laurent Poirot, Paris, FR;
Julien Valton, New York, NY (US);
Assignee:
CELLECTIS, Paris, FR;
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/00 (2006.01); A61K 35/17 (2015.01); A61K 39/395 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01); C12N 15/113 (2010.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61K 39/39541 (2013.01); C07K 16/2818 (2013.01); C12N 5/0636 (2013.01); C12N 15/113 (2013.01); C12N 2310/14 (2013.01); C12N 2510/00 (2013.01);
Abstract
The invention pertains to the field of adoptive cell immunotherapy. It provides with engineered immune cells comprising genetic alteration into genes which are involved into immune functions downregulation, especially in response to environment signals such as nutrients depletion. Such method allows the production of more potent immune cells in the context of tumors' microenvironment.