The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 13, 2024

Filed:

Oct. 03, 2014
Applicant:

Bio-rad Laboratories, Inc., Hercules, CA (US);

Inventors:

Michael Samuels, Windham, NH (US);

Jeffrey Olson, Chelmsford, MA (US);

Darren R. Link, Lexington, MA (US);

Assignee:

Bio-Rad Laboratories, Inc., Hercules, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C12P 19/34 (2006.01); G16B 20/10 (2019.01); G16B 20/00 (2019.01);
U.S. Cl.
CPC ...
G16B 20/10 (2019.02); G16B 20/00 (2019.02);
Abstract

In certain aspects, methods of the invention involve performing modification state specific enzymatic reaction of nucleic acid in a sample, determining a value associated with efficiency of the modification state specific enzymatic reaction based on a control, determining an amount of target nucleic acid in the sample, and normalizing the amount of target nucleic acid based on the efficiency value. Based on the normalized amount of target nucleic acid, the method further includes determining whether the normalized amount of target nucleic acid is indicative of a condition.


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