The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 13, 2024
Filed:
Nov. 07, 2018
J-pharma Co., Ltd., Yokohama, JP;
National University Corporation Gunma University, Maebashi, JP;
Osaka University, Suita, JP;
Hitoshi Endou, Yokohama, JP;
Goshi Ishihara, Yokohama, JP;
Kyoichi Kaira, Hidaka, JP;
Yoshikatsu Kanai, Suita, JP;
J-PHARMA CO., LTD., Yokohama, JP;
NATIONAL UNIVERSITY CORPORATION GUNMA UNIVERSITY, Maebashi, JP;
OSAKA UNIVERSITY, Suita, JP;
Abstract
Methods are provided for predicting a response to an anti-PD-1 antibody or anti-PD-L1 antibody therapy based on a new biomarker and for evaluating a malignancy of cancer. The method for predicting a response of a subject to an anti-PD-1 antibody or anti-PD-L1 antibody therapy includes measuring an expression level of LAT1 in a sample collected from a cancer tissue of the subject; and predicting a response of the subject to the anti-PD-1 antibody or anti-PD-L1 antibody therapy based on the expression level of LAT1. The method for evaluating a malignancy of cancer in a subject includes staining a sample collected from a cancer tissue of the subject with an anti-LAT1 antibody and an anti-PD-L1 antibody; and evaluating a malignancy of the cancer in the subject based on a presence or absence of a LAT1-positive and PD-L1-positive site.