The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 13, 2024
Filed:
Mar. 30, 2016
Applicant:
City of Hope, Duarte, CA (US);
Inventors:
John Williams, Monrovia, CA (US);
Krzysztof P. Bzymek, Pasadena, CA (US);
David Horne, Altadena, CA (US);
Jun Xie, Duarte, CA (US);
Assignee:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); C07K 16/02 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/725 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 16/02 (2013.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01); C07K 14/7051 (2013.01); C07K 16/2869 (2013.01); A61K 2039/505 (2013.01); A61K 2039/58 (2013.01); A61K 2039/64 (2013.01); C07K 2317/55 (2013.01); C07K 2317/60 (2013.01); C07K 2317/92 (2013.01); C07K 2319/00 (2013.01); C07K 2319/01 (2013.01);
Abstract
Provided herein are functionalized monoclonal antibodies (mAbs) including antibody fragments, including those where a Fab-binding molecule (Fab binding moiety) linked to a steric hindering molecule (steric hindering chemical moiety) is mechanically interlocked (e.g., through noncovalent conjugation) with the antibody or antibody fragment. Also provided are compositions that form highly stable and versatile drug delivery and diagnostic compositions.