The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 13, 2024
Filed:
Dec. 17, 2021
Ablynx N.v., Zwijnaarde, BE;
Sanofi, Paris, FR;
Heidi Rommelaere, Ghent, BE;
Christian Asbrand, Frankfurt am Main, DE;
Nadine Biesemann, Zwijnaarde, BE;
Ann Brigé, Ertvelde, BE;
Sigrid Cornelis, St. Martens-Lataem, BE;
Karen Heyninck, Zwijnaarde, BE;
Eric Lorent, Zwijnaarde, BE;
Shanna Van Zwam, Ghent, BE;
Ablynx N.V., Zwijnaarde, BE;
Sanofi, Paris, FR;
Abstract
The present disclosure provides a novel type of drug for treating a subject suffering from an inflammatory and/or autoimmune disease, and specifically rheumatoid arthritis. Specifically, the disclosure provides polypeptides comprising at least three immunoglobulin single variable domains (ISVDs), characterized in that at least one ISVD binds to TNF-α and at least two ISVDs bind to IL-6. The present disclosure also provides nucleic acids, vectors and compositions.