The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 13, 2024
Filed:
Nov. 28, 2022
Hongene Biotech Corporation, Union City, CA (US);
Wing C. Poon, Union City, CA (US);
Ruiming Zou, Union City, CA (US);
Aldrich N. K. Lau, Palo Alto, CA (US);
David Yu, Union City, CA (US);
Gengyu Du, Union City, CA (US);
Yun-Chiao Yao, Union City, CA (US);
Gang Zhao, Union City, CA (US);
Hongene Biotech Corporation, Union City, CA (US);
Abstract
Embodiments of the present application relate to the preparation of 2′-O-protected nucleoside phosphoramidites and conjugation of the 2′-O-protected nucleoside to a solid support. More specifically, the present application relates to nucleosides having a hydroxy protecting group at the 2′ position that reduces migration to the 3′ position during RNA (e.g., mRNA) synthesis and can be readily removed under mild conditions without the use of toxic metal-containing reagents. Methods of using the nucleosides described herein in RNA synthesis are also disclosed.