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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11896634 B1

PDFFull Text
Date of Patent:
Feb. 13, 2024

Filed:

Apr. 20, 2018

Oncolytic virotherapy with helper-dependent adenoviral-based vectors expressing immunomodulatory molecules

Applicant:

Baylor College of Medicine, Houston, TX (US);

Inventors:

Masataka Suzuki, Houston, TX (US);

Amanda Rosewell Shaw, Pearland, TX (US);

Caroline Elaine Porter, Houston, TX (US);

Norihiro Watanabe, Houston, TX (US);

Malcolm K. Brenner, Bellaire, TX (US);

Assignee:

Baylor College Of Medicine, Houston, TX (US);

Attorney:

Wolf, Greenfield & Sacks, P.C.

Primary Examiner:

Zachary C Howard

Int. Cl.
CPC ...
A61P 35/00 (2006.01); A61K 35/761 (2015.01); A61K 38/20 (2006.01); A61K 39/395 (2006.01); A61K 38/16 (2006.01); C12N 15/86 (2006.01); A61K 35/17 (2015.01); A61K 38/43 (2006.01); A61K 38/17 (2006.01); C12N 15/861 (2006.01); C07K 14/54 (2006.01); C07K 16/28 (2006.01); C07K 16/32 (2006.01); C07K 14/705 (2006.01); C07K 14/725 (2006.01);
U.S. Cl.
CPC ...
A61K 35/761 (2013.01); A61K 35/17 (2013.01); A61K 38/1774 (2013.01); A61K 38/208 (2013.01); A61K 38/43 (2013.01); A61K 39/3955 (2013.01); A61P 35/00 (2018.01); C12N 15/861 (2013.01); C07K 14/5434 (2013.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 16/2818 (2013.01); C07K 16/32 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01); C07K 2317/622 (2013.01); C07K 2317/73 (2013.01); C07K 2319/03 (2013.01); C07K 2319/33 (2013.01); C12N 15/86 (2013.01); C12N 2710/10343 (2013.01);
Abstract

The present disclosure concerns combination therapy for cancer that utilizes (i) an oncolytic virus; (ii) a virus comprising nucleic acid encoding an immunomodulatory factor; and (iii) at least one cell comprising a chimeric antigen receptor (CAR) specific for a cancer cell antigen. In particular embodiments, the virus comprises nucleic acid encoding an immunomodulatory factor comprises nucleic acid encoding IL-12 and/or antagonist anti-PD-L1 antibody.

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Suzuki, Masataka. (2024). Oncolytic virotherapy with helper-dependent adenoviral-based vectors expressing immunomodulatory molecules (U.S. Patent No. 11896634). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11896634

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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