The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 13, 2024
Filed:
Oct. 14, 2021
Applicant:
University of Cincinnati, Cincinnati, OH (US);
Inventors:
Jianjun Chen, Cincinnati, OH (US);
Rui Su, Cincinnati, OH (US);
Assignee:
University of Cincinnati, Cincinnati, OH (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/194 (2006.01); A61P 35/02 (2006.01); A61K 31/203 (2006.01); A61K 31/704 (2006.01); A61K 31/7068 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/194 (2013.01); A61K 9/0019 (2013.01); A61P 35/02 (2018.01); A61K 31/203 (2013.01); A61K 31/704 (2013.01); A61K 31/7068 (2013.01);
Abstract
Pharmaceutical compositions, kits and methods for treating tumors such as glioma and cancers such as leukemia with (R)-2-hydroxyglutarate (R-2HG) are provided, along with therapeutic regimens including treatment of a patient suffering from glioma or leukemia with a MYC-signaling inhibitor followed by or cotemporaneous with treatment with R-2HG, and optionally other chemotherapeutic agents.