The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 06, 2024

Filed:

Jul. 05, 2018
Applicants:

The Johns Hopkins University, Baltimore, MD (US);

The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);

Inventors:

Dax Fu, Short Hills, NJ (US);

Chengfeng Merriman, Essex, MD (US);

Hongjie Dai, Stanford, CA (US);

Hao Wan, Stanford, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); G01N 33/564 (2006.01); G01N 21/64 (2006.01);
U.S. Cl.
CPC ...
G01N 33/6893 (2013.01); G01N 21/6428 (2013.01); G01N 33/564 (2013.01); G01N 2021/6439 (2013.01); G01N 2800/042 (2013.01);
Abstract

Methods of detecting ZNT8 antibodies in serum are described. The methods include proteoliposomes comprising a transmembrane domain (TMD) and a cytosolic domain (CTD) of ZnT8 proteins exposed on the exterior of the proteoliposome; serum comprising antibodies targeting the ZnT8 proteins; and labelled captured autoantibodies that bind to ZnT8 antibodies.


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