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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11891655 B1

PDFFull Text
Date of Patent:
Feb. 06, 2024

Filed:

Apr. 26, 2022

Probe for selectively characterizing enzymes involved in xenobiotic metabolism and method of making and using the same

Applicant:

Battelle Memorial Institute, Richland, WA (US);

Inventors:

Aaron T. Wright, Richland, WA (US);

Susan Ramos-Hunter, Madison, WI (US);

Christopher Whidbey, Seattle, WA (US);

Assignee:

Battelle Memorial Institute, Richland, WA (US);

Attorney:

Klarquist Sparkman, LLP

Primary Examiner:

Jezia Riley

Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C12Q 1/6837 (2018.01); C07K 1/13 (2006.01); C12Q 1/6841 (2018.01); C12Q 1/48 (2006.01); C07D 311/16 (2006.01); C07D 405/04 (2006.01); C07C 233/33 (2006.01); C07C 233/20 (2006.01); C07C 247/00 (2006.01); G01N 33/58 (2006.01); C07C 305/22 (2006.01); C07D 203/26 (2006.01); C07C 247/12 (2006.01); C07C 203/04 (2006.01); C07C 271/28 (2006.01); C07D 405/12 (2006.01); C07H 19/067 (2006.01); C07H 15/203 (2006.01); C12Q 1/34 (2006.01); C07C 317/40 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6837 (2013.01); C07C 203/04 (2013.01); C07C 233/20 (2013.01); C07C 233/33 (2013.01); C07C 247/00 (2013.01); C07C 247/12 (2013.01); C07C 271/28 (2013.01); C07C 305/22 (2013.01); C07C 317/40 (2013.01); C07D 203/26 (2013.01); C07D 311/16 (2013.01); C07D 405/04 (2013.01); C07D 405/12 (2013.01); C07H 15/203 (2013.01); C07H 19/067 (2013.01); C07K 1/13 (2013.01); C12Q 1/34 (2013.01); C12Q 1/48 (2013.01); C12Q 1/6841 (2013.01); G01N 33/582 (2013.01); G01N 33/583 (2013.01); C12Q 2565/514 (2013.01); C12Q 2600/106 (2013.01); G01N 2333/91177 (2013.01);
Abstract

Activity-based probes that can be used to selectively identify and characterize enzymes that are involved in different phases of xenobiotic metabolism in a host and its microbiota population(s) are described. The activity-based probes described specifically label only their target active enzymes involved in xenobiotic metabolism and therefore provide a measurement of true protein functional activity rather than transcript or protein abundance. The activity-based probes also provide multimodal profiling of these active enzymes. Methods for preparing the activity based probes and exemplary methods for their use also are disclosed.

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