The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2024
Filed:
Dec. 13, 2022
Applicant:
Glaxosmithkline Biologicals SA, Rixensart, BE;
Inventor:
Andrew Geall, Littleton, MA (US);
Assignee:
GLAXOSMITHKLINE BIOLOGICALS SA, Rixensart, BE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/117 (2010.01); C12N 15/86 (2006.01); A61K 39/155 (2006.01); A61K 39/39 (2006.01); A61K 39/12 (2006.01); A61P 31/12 (2006.01); A61P 37/04 (2006.01); A61K 48/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C12N 15/117 (2013.01); A61K 39/12 (2013.01); A61K 39/155 (2013.01); A61K 39/39 (2013.01); A61K 48/0041 (2013.01); A61K 48/0083 (2013.01); A61P 31/12 (2018.01); A61P 37/04 (2018.01); C12N 15/86 (2013.01); A61K 2039/53 (2013.01); A61K 2039/552 (2013.01); A61K 2039/55555 (2013.01); A61K 2039/55566 (2013.01); C12N 2760/18534 (2013.01); C12N 2770/36143 (2013.01); C12N 2820/60 (2013.01);
Abstract
RNA encoding an immunogen is delivered to a large mammal at a dose of between 2 μg and 100 μg. Thus, the invention provides a method of raising an immune response in a large mammal, comprising administering to the mammal a dose of between 2 μg and 100 μg of immunogen-encoding RNA. Similarly, RNA encoding an immunogen can be delivered to a large mammal at a dose of 3 ng/kg to 150 ng/kg. The delivered RNA can elicit an immune response in the large mammal.