The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2024
Filed:
Dec. 17, 2021
Applicant:
Curamys Co., Ltd., Seoul, KR;
Inventors:
Jung-Joon Sung, Seoul, KR;
Ki Yoon Kim, Seoul, KR;
Assignee:
CURAMYS CO., LTD., Seoul, KR;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/113 (2010.01); A61P 21/00 (2006.01); C12Q 1/6883 (2018.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61P 21/00 (2018.01); C12Q 1/6883 (2013.01); C12N 2310/141 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/178 (2013.01);
Abstract
The present invention relates to use of miR-18b for prevention, treatment, or diagnosis of muscle diseases or neuromuscular diseases, and specifically it was confirmed that, in a muscle disease by gene mutations model, gene mutations reduce miR-18b expression, cause dysregulation of miR-18b signaling pathways, and thus induce calcium signaling, cell differentiation inhibition, and apoptosis. Therefore, miR-18b of the present invention may be used as a target factor for diagnosing and treating muscle diseases caused by gene mutations such as ALS and DMD.