The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2024
Filed:
Jan. 14, 2021
Virginia Commonwealth University, Richmond, VA (US);
Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA (US);
Paul B. Fisher, Henrico, VA (US);
Maurizio Pellecchia, Riverside, CA (US);
Swadesh K. Das, Richmond, VA (US);
Timothy P. Kegelman, Richmond, VA (US);
Bainan Wu, Richmond, VA (US);
Surya K. De, Richmond, VA (US);
Jun Wei, La Jolla, CA (US);
Mitchell E. Menezes, Richmond, VA (US);
Luni Emdad, Richmond, VA (US);
VIRGINIA COMMONWEALTH UNIVERSITY, Richmond, VA (US);
SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, La Jolla, CA (US);
Abstract
Provided herein are, inter alia, compositions that bind to a PDZ1 domain of MDA-9/Syntenin (syndecan binding protein: SDCBP), thereby inhibiting MDA-9/Syntenin activity, and methods of use of same. The compositions and methods provided herein are useful for treating cancer and preventing cancer metastasis, particularly in cancers that have increased MDA-9/Syntenin expression.