The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2024
Filed:
Aug. 05, 2019
The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Trustees of Dartmouth College, Hanover, NH (US);
Barney Graham, Rockville, MD (US);
Rebecca Loomis, Bethesda, MD (US);
Guillaume Stewart-Jones, Cambridge, MA (US);
John Mascola, Rockville, MD (US);
Jason McLellan, Austin, TX (US);
The United States of Americam as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US);
Trustees of Dartmouth College, Hanover, NH (US);
Abstract
Embodiments of immunogens comprising a recombinant Nipah virus (NiV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also provided are embodiments of immunogens comprising chimeric proteins comprising the recombinant NiV F ectodomain trimer and one or more G ectodomains, a multimer of NiV G ectodomains, and protein nanoparticles comprising the recombinant NiV F ectodomain trimer or an NiV G ectodomain. Also disclosed are nucleic acids encoding the immunogens and methods of their production. Methods for inducing an immune response in a subject by administering a disclosed immunogen to the subject are also provided. In some embodiments, the immune response treats or inhibits NiV infection in a subject.