The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2024
Filed:
Aug. 25, 2021
Applicant:
Children's Hospital Medical Center, Cincinnati, OH (US);
Inventors:
Karnail Singh, Deerfield Township, OH (US);
Paul Spearman, Cincinnati, OH (US);
Assignee:
Children's Hospital Medical Center, Cincinnati, OH (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/12 (2006.01); A61K 39/00 (2006.01); C12N 7/00 (2006.01); A61P 37/02 (2006.01); C07K 14/08 (2006.01);
U.S. Cl.
CPC ...
A61K 39/12 (2013.01); C07K 14/08 (2013.01); C12N 7/00 (2013.01); A61K 2039/5258 (2013.01); C12N 2740/10023 (2013.01); C12N 2740/11023 (2013.01); C12N 2740/12023 (2013.01); C12N 2740/13023 (2013.01); C12N 2740/14023 (2013.01); C12N 2740/15023 (2013.01); C12N 2740/16022 (2013.01); C12N 2740/16023 (2013.01); C12N 2760/14123 (2013.01); C12N 2760/14134 (2013.01);
Abstract
Disclosed herein are virus-like particle (VLP)-based bivalent vaccine compositions. The compositions may comprise a spherical retroviral Group-specific Antigen ('Gag') protein core and at least two Ebola glycoproteins. The at least two Ebola glycoproteins may be located at the exterior surface of the spherical Gag protein core, such that the VLP-based vaccine presents at least two Ebola glycoprotein antigens. In one aspect, the at least two Ebola glycoproteins are a(EBOV) glycoprotein, and a(SUDV) glycoprotein.