The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Feb. 06, 2024
Filed:
Sep. 23, 2020
Applicant:
Mirati Therapeutics, Inc., San Diego, CA (US);
Inventors:
David Briere, San Diego, CA (US);
James Gail Christensen, San Diego, CA (US);
Peter Olson, San Diego, CA (US);
Assignee:
Mirati Therapeutics, Inc., San Diego, CA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/519 (2006.01); A61P 35/04 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 31/519 (2013.01); A61P 35/04 (2018.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01);
Abstract
The present invention relates to combination therapies for treating KRas G12C cancers. In particular, the present invention relates to methods of treating cancer in a subject in need thereof, comprising administering to the subject a therapeutically effective amount of a combination of a an agent that blocks Programmed Death-1 receptor (PD-1) and Programmed Death Ligand-1 (PD-L1) signaling and a KRAS G12C inhibitor of Formula (I), Formula I-A or Formula I-B, kits comprising the compositions and methods of use therefor.