The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 30, 2024

Filed:

Nov. 26, 2014
Applicant:

University of North Texas Health Science Center AT Fort Worth, Fort Worth, TX (US);

Inventor:

Sid E. O'Bryant, Aledo, TX (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/68 (2006.01); G16B 40/00 (2019.01); C12Q 1/6883 (2018.01); G16H 50/20 (2018.01); G16B 40/20 (2019.01); G16B 40/30 (2019.01); G16H 50/30 (2018.01);
U.S. Cl.
CPC ...
G01N 33/6896 (2013.01); C12Q 1/6883 (2013.01); G16B 40/00 (2019.02); G16B 40/20 (2019.02); G16B 40/30 (2019.02); G16H 50/20 (2018.01); G16H 50/30 (2018.01); C12Q 2600/106 (2013.01); C12Q 2600/158 (2013.01); G01N 2800/2814 (2013.01); G01N 2800/52 (2013.01); G01N 2800/60 (2013.01); G01N 2800/7095 (2013.01);
Abstract

The present invention includes methods for selecting a therapy for improved cognition as well as prevention of cognitive loss/dysfunction using one or more endophenotypes comprising: obtaining a sample from a subject; measuring biomarkers that differentiate between an inflammatory, a metabolic, a neurotrophic, and a depressive endophenotype; and selecting a course of treatment for the subject based on whether the subject is scored as having a high or a low endophenotype for one or more of the inflammatory, a metabolic, a neurotrophic, and a depressive endophenotypes.


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