The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 2024
Filed:
Jun. 30, 2022
Applicant:
Denali Therapeutics Inc., South San Francisco, CA (US);
Inventors:
Tina Giese, South San Francisco, CA (US);
Gunasekaran Kannan, Daly City, CA (US);
Mihalis S. Kariolis, San Mateo, CA (US);
Cathal S. Mahon, San Francisco, CA (US);
Assignee:
DENALI THERAPEUTICS INC., South San Francisco, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/00 (2006.01); C12N 9/14 (2006.01); A61P 3/00 (2006.01); A61K 38/46 (2006.01);
U.S. Cl.
CPC ...
C12N 9/14 (2013.01); A61K 38/46 (2013.01); A61P 3/00 (2018.01); C12Y 310/01001 (2013.01); C07K 2319/30 (2013.01);
Abstract
Provided herein are proteins, which are capable of being transported across the blood-brain barrier (BBB) and comprise sulfoglucosamine sulfohydrolase (SGSH) enzyme-Fc fusion polypeptides. Certain embodiments also provide methods of using such proteins to treat Sanfilippo syndrome A.