The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 2024
Filed:
Sep. 15, 2020
Celldex Therapeutics, Inc., Hampton, NJ (US);
Yan Yang, Hamden, CT (US);
Sreekala Mandiyan, Bloomfield, NJ (US);
Brett Robinson, Preston, CT (US);
Lida Kimmel, Chester, CT (US);
Yaron Hadari, Harrison, NY (US);
Timothy David Jones, Babraham, GB;
Francis Joseph Carr, Balmedie, GB;
Robert George Edward Holgate, Royston, GB;
Richard Weldon, Wädenswil, CH;
Celldex Therapeutics, Inc., Hampton, NJ (US);
Abstract
Provided herein are compositions, methods and uses involving antibodies that specifically bind to MET, a receptor tyrosine kinase, and modulate the expression and/or activity of MET. Also provided are uses and methods for managing, treating, or preventing disorders, such as cancer. In one aspect, provided herein is a monoclonal antibody or antigen-binding fragment thereof that binds to the Sema/PSI domain of human MET. Also provided herein is a kit comprising an antibody or antigen-binding fragment provided herein. Also provided herein is a method of managing, protecting against, or treating cancer in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of an antibody or antigen-binding fragment provided herein.