The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 30, 2024

Filed:

Jun. 08, 2022
Applicants:

The University of British Columbia, Vancouver, CA;

Provincial Health Services Authority, Vancouver, CA;

Inventors:

David Perrin, Vancouver, CA;

Mihajlo Todorovic, Vancouver, CA;

François Bénard, Vancouver, CA;

Chengcheng Zhang, Vancouver, CA;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/685 (2006.01); C07K 14/68 (2006.01); C07K 5/10 (2006.01); C07K 5/12 (2006.01); C07K 7/56 (2006.01); C07K 14/72 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/685 (2013.01); A61K 38/00 (2013.01);
Abstract

The invention described herein is based in part on the discovery of a protein/peptide crosslink, which introduces fluorescent properties, and which has been applied to synthesize analogues of melanocortin and amanitin as choice peptides to be explored in the context of isoindole peptides. Without limitation, it is expected that those trained in the art of peptide synthesis and stapling would appreciate the consequences of this invention such that other peptides of varied length can be similarly constrained by isoindole staples as featured herein.


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