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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 11884687 B1

PDFFull Text
Date of Patent:
Jan. 30, 2024

Filed:

Mar. 01, 2018

Boronated multifunctional targeting drug conjugates, their uses and methods for their preparation

Applicant:

Hovione Scientia Limited, Cork, IE;

Inventors:

Pedro Gois, Lisbon, PT;

Fabio Santos, Montelavar, PT;

Assignee:

Hovione Scientia Limited, Cork, IE;

Attorneys:

Conley Rose. P.C.

Rodney B. Carroll

Primary Examiner:

Alicia L Otton

Int. Cl.
CPC ...
C07F 5/02 (2006.01); A61K 47/64 (2017.01); A61K 47/66 (2017.01); A61K 47/55 (2017.01); A61K 47/60 (2017.01); A61K 47/69 (2017.01); A61K 49/00 (2006.01);
U.S. Cl.
CPC ...
C07F 5/025 (2013.01); A61K 47/55 (2017.08); A61K 47/60 (2017.08); A61K 47/643 (2017.08); A61K 47/66 (2017.08); A61K 47/6951 (2017.08); A61K 49/0039 (2013.01); A61K 49/0052 (2013.01); A61K 49/0054 (2013.01); A61K 49/0056 (2013.01);
Abstract

Tri-component multi-functional boronated complexes (B-complexes), featuring reversible covalent bonds, are described, which incorporate a drug; a water-soluble moiety (e.g. polyethylene glycol (PEG) chains, cyclodextrins); and a targeting unit. A B-complex core was assembled in one step, and proved to be stable in different biocompatible conditions, such as human plasma, though reversible for example in the presence of glutathione (GSH). This platform enabled the modular construction of the multifunctional conjugates exhibiting high selectivity towards, for example, folate-receptor-positive MDA-MB-231 cancer cells, having an ICin the low nanomolar range.

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Gois, Pedro. (2024). Boronated multifunctional targeting drug conjugates, their uses and methods for their preparation (U.S. Patent No. 11884687). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/11884687

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