The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 30, 2024

Filed:

Jun. 14, 2019
Applicants:

Astrazeneca Ab, Södertälje, SE;

Cancer Research Technology Limited, London, GB;

Inventors:

Maurice Raymond Verschoyle Finlay, Cambridge, GB;

Frederick Woolf Goldberg, Cambridge, GB;

Martin Richard Howard, Cambridge, GB;

Attilla Kuan Tsuei Ting, Cambridge, GB;

Assignees:

AstraZeneca AB, Södertälje, SE;

Cancer Research Technology Limited, London, GB;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 473/32 (2006.01); A61K 9/127 (2006.01); A61K 31/437 (2006.01); A61K 31/502 (2006.01); A61K 31/522 (2006.01); A61K 31/5377 (2006.01); A61K 31/704 (2006.01); A61N 5/10 (2006.01);
U.S. Cl.
CPC ...
C07D 473/32 (2013.01); A61K 9/127 (2013.01); A61K 31/437 (2013.01); A61K 31/502 (2013.01); A61K 31/522 (2013.01); A61K 31/5377 (2013.01); A61K 31/704 (2013.01); A61N 5/10 (2013.01); C07B 2200/13 (2013.01);
Abstract

The specification generally relates to compounds of Formula (I): (I) and pharmaceutically acceptable salts thereof, where R, A, Aand Ahave any of the meanings defined herein. The specification also relates to the use of such compounds and salts thereof to treat or prevent DNA-PK mediated disease, including cancer. The specification further relates to pharmaceutical compositions comprising such compounds and salts; kits comprising such compounds and salts; methods of manufacture of such compounds and salts; intermediates useful in the manufacture of such compounds and salts; and to methods of treating DNA-PK mediated disease, including cancer, using such compounds and salts.


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