The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 2024
Filed:
Aug. 22, 2019
Applicant:
Guizhou University, Guiyang, CN;
Inventors:
Assignee:
GUIZHOU UNIVERSITY, Guiyang, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 211/76 (2006.01); C07D 207/267 (2006.01); C07D 209/46 (2006.01);
U.S. Cl.
CPC ...
C07D 211/76 (2013.01); C07D 207/267 (2013.01); C07D 209/46 (2013.01);
Abstract
Disclosed is a simple synthesis method of lactam derivatives, comprising: with formamide functioning as both an amine source and a hydrogen source (hydrolyzed to produce formic acid), carrying out a cycloamination reaction on a raw material keto acid in the absence of a solvent or a catalyst to simply synthesize a lactam derivative. Compared with previous reports, the present disclosure has the following advantages: the time required for the reaction is greatly shortened, the selectivity is remarkably improved, a conversion rate of a keto acid derivative is greater than 99%, and the yield of the lactam derivative can reach 70% to 94%.