The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 30, 2024

Filed:

Sep. 15, 2020
Applicant:

The Board of Trustees of the University of Arkansas, Little Rock, AR (US);

Inventors:

Billy M. Hargis, Fayetteville, AR (US);

Neil R. Pumford, Bentonville, AR (US);

Marion Morgan, Springdale, AR (US);

Srichaitanya Shivaramaiah, Bangalore, IN;

Guillermo Tellez-Isaias, Fayetteville, AR (US);

Amanda Wolfenden, Pea Ridge, AR (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/39 (2006.01); A61K 8/99 (2017.01); A61K 31/722 (2006.01); A61K 35/68 (2006.01); A61K 39/012 (2006.01); A61K 39/02 (2006.01); A61K 39/112 (2006.01); A61K 39/108 (2006.01); A61K 39/08 (2006.01); A61K 39/085 (2006.01); A61K 39/09 (2006.01); A61K 39/12 (2006.01); A61K 39/145 (2006.01); A61K 39/00 (2006.01); A61K 31/7004 (2006.01); C08B 37/08 (2006.01); C08L 5/08 (2006.01); A61K 39/155 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39 (2013.01); A61K 8/99 (2013.01); A61K 31/7004 (2013.01); A61K 31/722 (2013.01); A61K 35/68 (2013.01); A61K 39/012 (2013.01); A61K 39/0241 (2013.01); A61K 39/0258 (2013.01); A61K 39/0275 (2013.01); A61K 39/0283 (2013.01); A61K 39/08 (2013.01); A61K 39/085 (2013.01); A61K 39/092 (2013.01); A61K 39/099 (2013.01); A61K 39/12 (2013.01); A61K 39/145 (2013.01); A61K 39/155 (2013.01); C08B 37/003 (2013.01); C08L 5/08 (2013.01); A61K 2039/521 (2013.01); A61K 2039/523 (2013.01); A61K 2039/5252 (2013.01); A61K 2039/54 (2013.01); A61K 2039/542 (2013.01); A61K 2039/552 (2013.01); A61K 2039/55505 (2013.01); A61K 2039/55544 (2013.01); A61K 2039/55566 (2013.01); A61K 2039/55572 (2013.01); A61K 2039/55577 (2013.01); A61K 2039/55583 (2013.01); A61K 2039/575 (2013.01); A61K 2039/6087 (2013.01); A61K 2039/62 (2013.01); C12N 2760/16034 (2013.01); C12N 2760/16122 (2013.01); C12N 2760/16134 (2013.01); C12N 2760/16171 (2013.01); Y02A 50/30 (2018.01);
Abstract

Adjuvants comprising chitosan cross-linked with an aldehyde or mannosylated chitosan are provided herein. Methods of making the adjuvants and methods of combining or linking the adjuvants with antigens are also provided. The adjuvant-antigen combinations can be used in vaccine formulations and the vaccine formulations can be used in methods to vaccinate animals against the source of the antigen or to enhance the immune response in a subject.


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