The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 2024
Filed:
Aug. 29, 2019
Applicant:
Fred Hutchinson Cancer Center, Seattle, WA (US);
Inventors:
Leonidas Stamatatos, Seattle, WA (US);
Andrew McGuire, Seattle, WA (US);
Katherine Rachael Parks, Seattle, WA (US);
Matthew D. Gray, Seattle, WA (US);
Assignee:
Fred Hutchinson Cancer Center, Seattle, WA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/21 (2006.01); A61K 39/02 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/02 (2013.01); A61K 2039/545 (2013.01); C12N 2740/16034 (2013.01); C12N 2740/16134 (2013.01);
Abstract
Sequential immunization strategies to guide the maturation of antibodies against the human immunodeficiency virus (HIV) are described. The sequential immunization strategies utilize an HIV envelope protein (Env) that binds germline (gl) B cells as a first (prime) immunization and an Env with a functional glycosylated N276 as a second (boost) immunization. The sequential immunization strategies successfully elicit neutralizing antibodies against HIV.