The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 2024
Filed:
Jun. 25, 2018
Acibadem Mehmet Ali Aydinlar Universitesi, Atasehir/Istanbul, TR;
Sabanci Universitesi, Tuzla/Istanbul, TR;
Koc Universitesi, Sariyer/Istanbu, TR;
Meltem Muftuoglu, Atasehir/Istanbul, TR;
Batu Erman, Tuzla/Istanbul, TR;
Burak Erman, Sariyer/Istanbul, TR;
ACIBADEM MEHMET ALI AYDINLAR UNIVERSITESI, Atasehir/Istanbul, TR;
SABANCI UNIVERSITESI, Tuzla/Istanbul, TR;
KOC UNIVERSITESI, Sariyer/Istanbul, TR;
Abstract
Pol γ protein inhibitor compounds are useful for selectively inhibiting the growth of MLH1 mutant/deficient tumor or cancer cells due to a synthetic lethal relationship between MLH1 and Pol γ. The compounds were shown to directly interact with Pol γ and inhibit its biological function and cause cancer cell death and an inhibition of tumor or cancer cell growth in multiple assays.