The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 30, 2024
Filed:
Jun. 25, 2021
Institute for Cancer Research, Philadelphia, PA (US);
Institut Curie, Paris, FR;
Institut DE Genetique ET DE Biologie Moleculaire ET Cellulaire, Illkrich, FR;
Alfonso Bellacosa, Philadelphia, PA (US);
Rossella Tricarico, Philadelphia, PA (US);
Tim Yen, Philadelphia, PA (US);
Vikram Bhattacharjee, Philadelphia, PA (US);
Pietro Mancuso, Philadelphia, PA (US);
Lionel Larue, Paris, FR;
Irwin Davidson, Ilkrich, FR;
Abstract
The invention provides compositions, kits, and methods for inducing growth arrest, differentiation, or senescence of cancer cells that express thymine DNA glycosylase, and treating the cancer accordingly. The methods comprise inhibiting expression or biologic activity of thymine DNA glycosylase in cancer cells. Inhibition of thymine DNA glycosylase in cancer cells may induce the cells to revert to a healthy, non-cancerous phenotype and/or may induce the cells to senesce. Cancer cells include melanoma, lung, prostate, pancreatic, ovarian, brain, colon, recto-sigmoid colon, and breast cancer cells.