The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 23, 2024
Filed:
Feb. 05, 2021
Applicant:
William Marsh Rice University, Houston, TX (US);
Inventors:
Assignee:
William Marsh Rice University, Houston, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12Q 1/68 (2018.01); C07H 21/02 (2006.01); C12Q 1/6832 (2018.01); C12Q 1/6811 (2018.01); C07H 21/04 (2006.01); C07H 1/06 (2006.01); C12Q 1/6876 (2018.01); G01N 33/00 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6832 (2013.01); C07H 1/06 (2013.01); C07H 21/02 (2013.01); C07H 21/04 (2013.01); C12Q 1/6811 (2013.01); C12Q 1/6876 (2013.01);
Abstract
This invention describes a method of controlling the hybridization yield of nucleic acid probes by adjusting the relative concentrations of auxiliary oligonucleotides to the probes and the targets. The auxiliary oligonucleotide is partially or fully complementary to either the probe or the target, and is released upon hybridization of the probe to the target.