The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 23, 2024
Filed:
Sep. 21, 2018
Applicant:
The Children's Medical Center Corporation, Boston, MA (US);
Inventors:
Paolo Fiorina, Boston, MA (US);
Moufida Ben-Nasr, Boston, MA (US);
Assignee:
THE CHILDREN'S MEDICAL CENTER CORPORATION, Boston, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0789 (2010.01); A61K 35/12 (2015.01); A61K 35/28 (2015.01); A61P 3/10 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0647 (2013.01); A61K 35/12 (2013.01); A61K 35/28 (2013.01); A61P 3/10 (2018.01); C12N 2501/65 (2013.01);
Abstract
Described herein are methods and compositions for producing modified, PD-L1 expressing hematopoietic stem cells, and uses thereof. Aspects of the invention relate to modulating the expression of micro RNA that controls the expression of PD-L1 in the hematopoietic stem cell. Methods for modulating the expression of micro RNA include, e.g., introducing to the cell a nucleic acid encoding a given micro RNA, or an agent that inhibits a given micro RNA.