The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 23, 2024
Filed:
Mar. 03, 2018
Tusk Therapeutics Ltd., Hertfordshire, GB;
Cancer Research Technology Limited, London, GB;
Anne Goubier, Hertfordshire, GB;
Josephine Salimu, Hertfordshire, GB;
Kevin Moulder, Hertfordshire, GB;
Beatriz Goyenechea Corzo, Hertfordshire, GB;
Pascal Merchiers, Hertfordshire, GB;
Sergio Quezada, London, GB;
Karl Peggs, London, GB;
Frederick Arce Vargas, London, GB;
Isabelle Solomon, London, GB;
Tusk Therapeutics Ltd., Hertfordshire, GB;
Cancer Research Technology Limited, London, GB;
Abstract
The present disclosure relates to use of an anti-CD25 antibody, not inhibiting IL-2-CD25 interaction, with enhanced binding to activating Fc gamma Rs that lead to effective depletion of tumor-infiltrating Treg cells and improved control of established tumors. Combination with anti-programmed cell death protein-1 antibodies further improves tumor rejection.