The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 23, 2024

Filed:

May. 25, 2021
Applicant:

89bio Ltd, Herzliya, IL;

Inventors:

Robert L Hudkins, Chester Springs, PA (US);

David B. Whitman, Phoenixville, PA (US);

Craig A. Zificsak, Downingtown, PA (US);

Allison L. Zulli, Chesterbrook, PA (US);

Melody McWherter, Boyertown, PA (US);

Assignee:

89BIO LTD, Herzliya, IL;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 491/107 (2006.01); C07D 491/113 (2006.01);
U.S. Cl.
CPC ...
C07D 491/107 (2013.01); C07D 491/113 (2013.01);
Abstract

Described herein are spiropiperidine compounds according to Formula I that have demonstrated activity as fatty acid synthase inhibitors. Also described herein are pharmaceutical compositions containing the described spiropiperidine compounds, and methods of treating diseases mediated by fatty acid synthase, by administering one or more of the compounds or pharmaceutical formulations described herein. Also described herein are methods of synthesizing the compounds described, including the described spiropiperidine compounds and synthetic intermediates that are useful in those syntheses.


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