The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jan. 23, 2024

Filed:

Apr. 23, 2021
Applicant:

University of South Florida, Tampa, FL (US);

Inventors:

Ratka Damnjanovic, Oldsmar, FL (US);

Parveen Bazard, Tampa, FL (US);

Robert Dana Frisina, Tampa, FL (US);

Venkat Rama Bhethanabotla, Tampa, FL (US);

Assignee:

University of South Florida, Tampa, FL (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61N 5/06 (2006.01); A61N 1/36 (2006.01); B82Y 5/00 (2011.01);
U.S. Cl.
CPC ...
A61N 5/0622 (2013.01); A61N 1/36164 (2013.01); A61N 1/36167 (2013.01); A61N 5/0601 (2013.01); B82Y 5/00 (2013.01); A61N 2005/0632 (2013.01); A61N 2005/0663 (2013.01);
Abstract

A method of modulating neural activity using a combination of electrical and optical stimulation transmitted via a gold nanoparticle covered nanoelectrode is presented. The combination of short-duration green visible light optical pulses with the complementary sub-threshold level electric current pulses are capable of producing action potentials in neurons. Cells were found to have a greater than a 5× survival rate using this hybrid stimulation method as compared to pure plasmonic/optical stimulation. The cell stimulation success rate was 3× greater with hybrid stimulation.


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