The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 23, 2024
Filed:
Aug. 09, 2020
Applicant:
Inventprise, Llc, Redmond, WA (US);
Inventor:
Subhash V. Kapre, Redmond, WA (US);
Assignee:
Inventprise, Inc., Redmond, WA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/29 (2006.01); A61K 39/295 (2006.01); A61K 47/42 (2017.01); C07K 14/025 (2006.01); A61K 39/12 (2006.01); A61K 9/00 (2006.01); A61K 9/19 (2006.01); A61K 47/10 (2017.01); C07K 14/005 (2006.01); C12N 7/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/12 (2013.01); A61K 9/0019 (2013.01); A61K 9/19 (2013.01); A61K 47/10 (2013.01); A61K 47/42 (2013.01); C07K 14/005 (2013.01); C12N 7/00 (2013.01); A61K 2039/5258 (2013.01); C12N 2710/20034 (2013.01); C12N 2730/10123 (2013.01); C12N 2730/10142 (2013.01);
Abstract
The invention is directed to compositions and methods for the stabilization of viral and bacterial vaccines. Vaccines of the invention are contained in VLPs with stabilizing agents such as, for example, sugar alcohols (e.g., sorbitol) and degraded gelatins. Preferably the gelatin has an average molecular weight of 10,000 kilodaltons or less. These vaccines have a substantially improved thermostability as well as long term stability. The invention is also directed to the manufacture of a vaccine or the invention and methods for the administration of a vaccine of the invention to patients.