The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 23, 2024
Filed:
Sep. 10, 2019
Applicant:
Great Novel Therapeutics Biotech & Medicals Corporation, Taipei, TW;
Inventors:
Jia-Shiong Chen, Taipei, TW;
Mu-Hsuan Yang, Taipei, TW;
Cheng-Han Chou, Taipei, TW;
Yi-Hong Wu, Taipei, TW;
Sz-Hao Chu, Taipei, TW;
Ye-Su Chao, Taipei, TW;
Chia-Nan Chen, Taipei, TW;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4406 (2006.01); A61K 31/415 (2006.01); A61P 35/00 (2006.01); A61K 39/00 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4406 (2013.01); A61K 31/415 (2013.01); A61P 35/00 (2018.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); A61K 2039/507 (2013.01); C07K 2317/76 (2013.01);
Abstract
The present invention relates to a combination of a histone deacetylase (HDAC) inhibitor, chidamide in an acidic salt form, and a nonsteroidal anti-inflammatory drugs (NSAIDs), celecoxib in a basic salt form. The present invention also relates to methods which significantly regulate tumor microenvironment and therefore dramatically improve anti-cancer activity.